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Martina Rezácova and Jaroslav Pejchal, Journal of Applied Biomedicine, 10: 1-8, 2012, DOI:10.2478/v10136-012-0002-2

Fullerene – derivatives

Compounds developed based on nanotechnology, such as for example, carbon nanospheres named fullerenes (C60, C70, C80–C200) also represent an important group of antioxidants due to the possible absorption of many oxygen radicals in a single fullerene molecule (Bosi et al. 2003). The most abundant form of fullerenes is buckminsterfullerene C60 (Fig. 1) with 60 carbon atoms arranged in a spherical structure (Marković and Trajković 2008).

Antioxidant activity

Oxidative stress and associated oxidative damage are mediators of cellular injury in many pathological conditions, including autoimmunity, atherosclerosis, diabetes, and neurodegenerative disorders (Marković and Trajković 2008). In many studies, it has been shown that water-soluble fullerene derivates can act as antioxidant substances scavenging oxygen radicals (including ROS generated by ionizing radiation) and protecting cells and/or tissues against ROS damage.